For women, besides innovatieve and exceptional quality status of NK cells – three markes that I have mentioned before, two other markers that we check are: “embryo toxicity” and “blocking factors” – we check them from the serum of the lady, the level of the embryo toxins and blocking factors – that means if the results is negative because the reference is positive, then it has to be histocompatilbility with the husband – that means that there might be no pregnancy for many years and even the miscarriages for the rest of their life. It is the case when the couple is like relatives – they match so much together – it is very difficult for them because even if they perform many IVF, they might never have a successful pregnancy or healthy baby.
Video Answer from: Ioannis John Toliopoulos, PhD
Let me please refer to embryo toxicity because it is a very specific test that so far statistically, we have seen that 1 out of 4 ladies – which is 25% that are positive to embryo toxicity, even if they do hundred IVF trials, will never have a successful pregnancy.
That is very important because today for example, I have a patient only 28 years old and she was told that she needs to do IVF because for 3 years she never succeeded in getting pregnant with her husband. She is positive in embryo toxins and she also has a blocking factor with husband. The only solution in such cases is infusion of IVIG, there is specific bibliografi that IVIG in the two hours of infusion – it is long lasting infusion so the patient needs to be patient – releases the patient from embryo toxicity, dissolves these blocking factors. That means – it gives a chance to go. Duration is 8 months to 1 year with one infusion only. That means it gives the couple a chance to have a successful pregnancy whether the lady will go to natural conception or IVF trial.
We have many successful pregnancies, we have many healthy babies – at least the last 10 years when I am doing it professionally. People come from NIgeria, UK Germany and we have had success with couples that had more than 5 IVF trials so these two diagnostic markers are very important. They are covered with NK cells, the 80% the immune status of the lady. I say 80% because as members of the International Society of Reproductive Immunology, we are missing 20% to be 100% sure that we know the immune status of the lady. We lack the 20% but next I don’t know how many years, I think we will be much more comfortable with the immune status of the lady if we don’t have any genetic status. We have to admit that we avoid any genetic status and we concentrate only in immune status of the lady, then we will be 100% sure that we will regulate the immune status for the lady in 99, 99% and now we say we have high chances but we cannot say the specific number because we say scientifically the truth, I mean we do not make miracles. Miracles will come themselves by just the analysis and sciences.
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